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KMID : 0370220030470060376
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Yakhak Hoeji
2003 Volume.47 No. 6 p.376 ~ p.381
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2-Arylethenylchromones Derivatives : Synthesis and Anticancer Activity
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문창상/Moon CS
이경원/이지용/이재열/정봉영/이경태/이용섭/Lee KW/Lee JY/Lee JY/Chung BY/Lee KT/Lee YS
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Abstract
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2-Arylchromones, also known as flavones, are among the most ubiquitous classes of natural products occurring in the plant kingdom. On the other hand, 2-styrylchromones are rel atively scarce in nature and only a few compounds has been isolated from the blue-green algae species. Therefore, new 2-arylethenylchromone derivatives (4a~n, 5a~f) were synthesized by the aldol condensation of 2-methylchromone (3) with several aromatic aldehydes in order to evaluate their cytotoxicities using a MTT assay on three tumor cells. 2-Arylethenylchromene derivative 4a showed the significant cytotoxic activities on KB, HL-60 and P-388 cell lines with IC50 values of 25.2, 63.59 and 49.51 μM, respectively, indicating that 2-arylethenylchromone skeleton has a potential anti-tumor application.
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